Biochem/physiol Actions

Reversible: yes

Target IC₅₀: 10 µM against protein kinase C

Product does not compete with ATP.

Primary TargetPKC

Cell permeable: yes

General description

A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines.

A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Rohlff, C., et al. 1998. Prostate 37, 51.Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.Baltuch, G.H., et al. 1993. Neurosurgery33, 495.Powis, G. 1991. Trends Pharmacol. Sci.12, 188.Issandou, M., et al. 1990. Cancer Res.50, 5845.O'Brian, C.A., et al. 1985. Cancer Res.45, 2462.

Packaging

100 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)